Open Access
Research (Published online: 04-12-2021)
10. Severity assessment of single-dose Oxford-AstraZeneca vaccinated individuals infected with severe acute respiratory syndrome coronavirus 2 in Southeast Bangladesh
Eaftekhar Ahmed Rana, Pronesh Dutta, Md. Sirazul Islam, Tanvir Ahmad Nizami, Tridip Das, Sharmin Chowdhury and Goutam Buddha Das
International Journal of One Health, 7(2): 220-226

Eaftekhar Ahmed Rana: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Microbiology and Veterinary Public Health, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Pronesh Dutta: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Medicine and Surgery, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Md. Sirazul Islam: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Pathology and Parasitology, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Tanvir Ahmad Nizami: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Microbiology and Veterinary Public Health, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Tridip Das: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Poultry Research and Training Centre, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Sharmin Chowdhury: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Pathology and Parasitology, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Goutam Buddha Das: COVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh; Department of Animal Science and Nutrition, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.

doi: www.doi.org/10.14202/IJOH.2021.220-226

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Article history: Received: 12-07-2021, Accepted: 20-10-2021, Published online: 04-12-2021

Corresponding author: Md. Sirazul Islam

E-mail: sirazul@yahoo.com

Citation: Rana EA, Dutta P, Islam MS, Nizami TA, Das T, Chowdhury S, Das GB (2021) Severity assessment of single-dose Oxford-AstraZeneca vaccinated individuals infected with severe acute respiratory syndrome coronavirus 2 in Southeast Bangladesh, Int. J. One Health, 7(2): 220-226.
Abstract

Background and Aim: A vaccine program for coronavirus illness (coronavirus disease [COVID-19]) is currently underway in numerous regions of the world, including Bangladesh, but no health data on those who have been vaccinated are available at this time. The study aimed to investigate the health condition of people who had received their first dose of the Oxford- AstraZeneca vaccine and were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Materials and Methods: To detect SARS-CoV-2, a standard virological approach, real-time reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), was used. Several health indicators from vaccinated patients were collected using pre-structured questionnaires during the infection phase.

Results: A total of 6146 suspicious samples were analyzed, and 1752 were found to be positive for SARS-CoV-2, with 200 people receiving the first dose of the COVID-19 vaccine. One hundred and sixty-five (82.5%) were not hospitalized among the vaccinated people, and 177 (88.5%) did not have any respiratory problems. Only 8% of patients required further oxygen support, and 199 (99.5%) did not require intensive care unit intervention. Overall, oxygen saturation was recorded at around 96.8% and respiratory difficulties did not extend more than 5 days during the infection period. Among the vaccinated COVID-19-positive people, 113 (56.5%) and 111 (55.5%) had typical physiological taste and smell. Surprisingly, 129 (64.5%) people had diverse comorbidities, with high blood pressure (27.9%) and diabetes (32 [24.8%]) being the most common. The major conclusion of the current study was that 199 (99.5%) of vaccinated patients survived in good health and tested negative for RT-qPCR.

Conclusion: According to the findings of this study, administering the first dose of the Oxford-AstraZeneca vaccine considerably reduces health risks during the COVID-19 infection period.

Keywords: assessment, comorbidity, coronavirus disease, health risk, Oxford-AstraZeneca vaccine.